General

High fibrinogen: What it signifies, its causes symptoms and treatment

High levels of fibrinogen can cause blood clots within arteries and vessels, and can cause myocardial infarction and stroke. Find out all you can about it!

Regular blood tests may reveal levels of fibrinogen that are higher than the threshold that is allowed which can lead to the appearance of conditions and illnesses that are quite serious.

It is clear that there are standards for which to look and we can discuss excessive fibrinogen levels when recommended values are not met under normal circumstances.

What does high fibrinogen actually mean? It could be as a sign of risk for cardiovascular disease especially when combined with hypertension, high levels of triglycerides, and lower values of “good” cholesterol.

What’s the point of fibrinogen?

To know what fibrinogen does in blood tests, and also to know what the effect of high levels of fibrinogen in the human body it’s beneficial to learn about the nature and function of fibrinogen inside the body.

Fibrinogen is also known as coagulation factor I. It is amino acids along with a carbohydrate (glycoprotein) which is easily soluble in the natural environment.

The glycoprotein is produced at the hepatic level, and is absorbed within the bloodstream whenever it is required to help promote the process of hemostasis (blood coagulation).

 

In reality, through the the thrombin protein, fibrinogen gets transformed into fibrin i.e. the plasma protein has an elastic structure that absorbs plateslets as well as red blood cells. It creates blood clots, and blocks the flow of blood.

Normal levels of fibrinogen

Fibrinogen is involved within the reactions required to help clot blood when a vessel has been damaged.

To fulfill its purpose the fibrinogen concentration is required to be kept within certain limits: minimum 200 mg/dl; maximum 400 mg/dl, maximum limit for pregnant women of 700 mg/dl.

In the event of fibrinogen levels that are high, when should you be concerned? When the concentration is much higher than the threshold recommended by experts.

High Fibrinogen: Causes

The primary reasons for high fibrinogen could be nonpathologic or pathological in the nature (more connected to a lifestyle that is unhealthy).

Causes of pathology

Inflammation-related states may trigger an increase in the production of glycoprotein in the plasma.

Metabolic syndrome is a metabolic disorder occurs when there is several concomitant issues (dyslipidemia and hypertension, as well as hyperglycemia and weight gain) Pro-inflammatory condition triggers the production of inflammatory cytokines as well as the production of fibrinogen.

Hepatitis – Hepatitis can have different causes however, in all cases it triggers an inflammation that triggers the production fibrinogen, a glycoprotein.

Nephrotic syndrome Nephrotic syndrome is defined by a change in the renal blood vessels , which allow the movement of proteins with lower molecular mass in the urine, with the exception for fibrinogen (which remains in blood).

Cancer There is an association between fibrinogen levels and cancer. The advanced stage of cancer triggers a significant inflammation that causes the production of more glycoprotein and other factors.

Tuberculosis – Infections of the lungs occurs through the action of certain bacteria, and it causes the destruction of the lung’s structure.

Collagenopathies: In collagenopathies, like rheumatoidarthritis, Lupus and scleroderma the immune system attacks the tissues and triggers inflammation in various areas.

Causes that are not pathological

Pregnancy causes disruption to the body’s metabolism, which can increase the fibrinogen content to avoid all internal bleeding. Therefore, high levels of fibrinogen levels in pregnancy are normal. However, how high is fibrinogen in the course of pregnancy? It shouldn’t exceed 700 mg/dl.

Hormone therapy: You may be experiencing high fibrinogen levels if you are taking birth hormone pills or other medications during menopausal cycles. Why? The estrogen contained in is responsible for causing the glycoprotein’s levels to increase, which increases the chance of blood clots.

Aging in the body is impacted by physiologic ageing through altering normal elimination rate of fibrinogen (which may later turn out to be excessive).

Body mass index – The BMI is a measure of to a person’s weight and height measured in squares in order to establish their optimal weight. The greater the value is, the more likely you will be suffering from high levels of fibrinogen.

Burns – Burns increase the permeability the vessel walls, allowing proteins and other molecular-weight substances flow through. This results in a decrease of blood volume as well as the growth of glycoprotein.

Smoking tobacco can cause inflammation of the respiratory tract which in turn triggers fibrinogen production.

Symptoms

What are the signs associated with high fibrinogen? The condition isn’t ascribed to specific symptoms. This is the reason why diagnosis might not arrive quickly. In reality, the majority times, it’s diagnosed almost entirely on accident.

Diagnosis

A diagnosis of high-fibrinogen comes in the course of blood tests that are prescribed to determine the possibility of a problem with coagulation (eg bleeding frequently or the formation of a thrombus) or to identify the risk of developing cardiovascular disease.

The amount of fibrinogen is measured during pregnancy since fibrinogen during pregnancy is elevated at a physiological level however, it can be harmful. What is the reason why high levels of fibrinogen during pregnancy pose risk to the baby? There is a possibility of abruption of the placenta or ending the pregnancy.

It is recommended to have it checked in the period of convalescence following surgery to prevent thrombosis-related episodes.

The ability to determine the glycoprotein concentration in plasma by two tests: the activity test (the time it takes for fibrinogen to turn into fibrin in the clot formation process determines the amount of glycoprotein) and the quantitative test (measures the proportion of fibrinogen found in blood).

High fibrinogen Treatment

The first thing to note is that there is no cure for fibrinogen levels that are high because the changes in the glycoprotein’s concentration is contingent on another situation (pathological or not).

It is a given that treatment starts with the diagnosis of the root issue to the most appropriate method to return the situation to normal.

If it’s not caused by a pathological issue it is feasible to maintain fibrinogen levels within the range of recommended values.

What can be done to reduce the levels of fibrinogen? In particular it is advised to stay away from weight gain and eating junk food, smoking , and anxiety.

Hydration plays a crucial role in this regard as it helps to reduce the plasma element’s concentration.

 

Next Post